Association Test Based on SNP Set: Logistic Kernel Machine Based Test vs. Principal Component Analysis
نویسندگان
چکیده
منابع مشابه
Association Test Based on SNP Set: Logistic Kernel Machine Based Test vs. Principal Component Analysis
GWAS has facilitated greatly the discovery of risk SNPs associated with complex diseases. Traditional methods analyze SNP individually and are limited by low power and reproducibility since correction for multiple comparisons is necessary. Several methods have been proposed based on grouping SNPs into SNP sets using biological knowledge and/or genomic features. In this article, we compare the l...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0044978